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Rank of significantly altered lipid metabolites (detected in negative mode) in B16 cells treated with HDL versus LDL

Unlike conventional chemotherapeutic agents, curcumin can simultaneously modulate several critical oncogenic signaling pathways implicated in prostate cancer pathogenesis, such as phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin, nuclear factor kappa B, Wnt/-catenin, signal transducer and activator of transcription 3, and androgen receptor signaling (Shanmugam et al., 2015

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Standardization of time duration was performed in our previous experiments which showed that, 12 h duration (among the tested durations 1 h, 3 h, 6 h, 12 h, 24 h and 48 h) of hypoxia exposure was the optimum time, at which maximum renal damage had occurred 26