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Description
NNMT enzyme inhibition biochemical studies have characterised 5-Amino-1MQ as a potent, selective NNMT inhibitor in cell-free and cell-culture assays

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5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame
The compound's selectivity extends to its membrane permeability characteristics, which allow efficient cellular uptake without affecting membrane integrity or cellular viability up to 100 M concentrations
