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Lastly, the study elucidated the mechanism by which IFN- and SLE IgG induce neutrophil ferroptosis, namely, by promoting the binding of CREM to the Gpx4 promoter, leading to downregulation of GPX4 expression

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The GSH/GSSG-Glo Assay was performed on HEK-293 cells after treatment for 18 hours BSO in the presence and absence of CellTox Green Dye