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Interestingly, in doxorubicin-resistant tumors, inhibition of DNMTs also suppresses H3K27me3 and the Histone methyl transferase (HMT) associated with it, inhibiting global gene repression [177]

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Gene essentiality plot showing genes scores in untreated (x-axis) and ML210-treated (GPX4 inhibition) Karpas299 cells

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