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Recent evidence suggests that ferroptosis, a type of programmed cell death caused by iron accumulation and lipid peroxidation, contributes to AD pathogenesis

Loss of GLT1 in habenular astrocytes has been found to exacerbate depressionlike behavior

Conversely, other studies raise concerns about potential metabolic slowdown and negative impacts on weight loss sustainability, particularly in long-term fasting or in vulnerable populations such as women of reproductive age or individuals with subclinical hypothyroidism [9]

Moreover, the study provides evidence suggesting that B12, acting as an epidrug, shows promise as a therapeutic approach for addressing this cognitive impairment