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DECLARATIONS Acknowledgments The authors are grateful to Sabine Weiskirchen (RWTH University Hospital Aachen) for preparing the graphical abstract for this contribution
insert the needle at 4590 into subcutaneous tissue [5] [8]

Alexa Fluor 488 annexin V/dead cell apoptosis kit was purchased from Invitrogen (Carlsbad, CA, USA)

Second, they are most common during escalation periods and tend to decrease as the body adapts
