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The recommended dose of pemetrexed for injection when administered with pembrolizumab and platinum chemotherapy for the initial treatment of metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered after pembrolizumab and prior to carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles

Most of the evidence giving rise to this claim comes from a few observational studies

Patients should ensure they are registered with a GP who is aware of their surgical history and should attend all recommended follow-up appointments, as early detection of deficiency allows for timely intervention before irreversible complications develop

Keep them away from heat