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Ito H., Shoji Y., Ueno M., Matsumoto K., Nakanishi I., Pharmaceutica 2023, 15, 2536

This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

Greenwald, J

Some suggest AOD 9604 may preferentially target stubborn fat cells (areas with higher fat storage) and may also exert beneficial effects on cartilage/ bone/ connective tissue (though those are more speculative)
