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It is also important to note that the elderly have significantly lower levels of different B vitamins, even in the case of the recommended dietary intake or no signs of comorbidities [228,229,230]

However, no significant changes were observed in these proteins (Supplemental Figure 4G), suggesting that the suppression of lipogenesis via FASN oxidation is independent of Notch signaling

Patients manifest progressive cerebellar and sensory ataxia, dysarthria, lower limb pyramidal weakness, and other systemic manifestations

In in vitro permeation tests, after 36 h of administration, the cumulative permeation and cumulative permeation rate of SH in SHTs were ap-proximately 1.7 times those in SHLs