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GLOW was already trending

These epidrugs are typically small-molecule DNMT inhibitors that directly affect catalytic sites, whose mechanism of action is unrelated to DNA incorporation

However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo , albeit at a high 1,000 mg dose, with IC 50 values of 25.8 and 113.7 M, respectively

Mitochondria, as the primary energy producers and regulators of redox homeostasis, become dysfunctional under these pathological conditions, resulting in an imbalance favoring ROS accumulation (Xu and Yang, 2025
