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The intestinal microecological disorder of NAFLD is characterized by the imbalance of flora-intestinal-hepatic axis, and the present study systematically reveals that ginseng can improve the metabolic abnormalities by regulating the homeostasis of intestinal flora in a multi-dimensional way (Figure 5) ( High-fat diets increases intestinal permeability and exposes the liver to endotoxins, and a disturbed gut microbiota also disrupts the intestinal vascular barrier, enhancing intestinal permeability and bacterial lipopolysaccharide leakage into the circulation (Mouries et al., 2019)