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This was explained as ATZ causes oxidative stress by forming ROS 71 , lipid peroxidation and antioxidant depletion 72

The key role of GSH as an antioxidant is demonstrated by many studies showing that experimental depletion of GSH levels which can be achieved with various chemicals the most used of which is buthionine sulfoximine (BSO) an inhibitor of GSH synthesis has a worsening effect in many disease models

Effectiveness of Glutathione Supplementation As we explore the effectiveness of glutathione supplementation in individuals with autism, we also have to consider the methods of administration and the impact on glutathione levels in children with autism