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We've seen how disruptions in metabolic pathways contribute to a sprawling list of health challenges, from obesity and type 2 diabetes to various metabolic syndromes

Clinical data show that inflamed or "hot" tumors, which exhibit higher levels of immune cell infiltration, generally respond more effectively to ICBs therapy [6]

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.He Y, Huang W, Zhang C, Chen L, Xu R, Li N, Wang F, Han L, Yang M, Zhang D

Therefore, pharmacological targeting of these compounds could transform geriatric medicine by preventing or delaying telomeric attrition and/or the onset of metabolic diseases such as metabolic syndrome (MetS), where senescence could be contributing by increasing systemic inflammation and insulin resistance in T2DM [74,78,79,80,81]