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Despite the high prevalence of this condition, there is widespread heterogeneity regarding routes, schedules and dosages of vitamin B12 administration

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Transdermal rivastigmine (MD=2.11, 95% CI: 0.04 to 4.26), and the combinations donepezil +memantine, galantamine +memantine (MD=2.24, 95% CI: 2.13 to 6.61), and transdermal rivastigmine +memantine (MD=1.79, 95% CI: 1.70 to 5.27) were associated with a MD from placebo of more than 1.40 MMSE points
