glutathione to treat acetaminophen overdose Illustration of the effects of on glutathione, 5️⃣ Antidote: NAC (N-acetylcysteine) NAC
Description
In pancreatic cells, excessive production of ROS promotes cell dysfunction and apoptosis, ultimately leading to insufficient insulin secretion [124]
Additionally, the antioxidant nature of NAC has an inhibitory effect on NF-B and, thus, increases the expression of GDF-9
10.1038/ncb1881 82 ItohY.EsakiT.ShimojiK.CookM.LawM
[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Mordaunt C.E., Jianu J.M., Laufer B.I., Zhu Y., Hwang H., Dunaway K.W., Bakulski K.M., Feinberg J.I., Volk H.E., Lyall K., et al
