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In treating solid tumors, developing more tumor-targeting ASNase is one aspect, and the SLC1A3 inhibitor mentioned earlier also provides an idea to solve this problem

During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

To confirm that HA coating enhances cell uptake in CSC-enriched 4T1 cells, we selected an anti-CD44 antibody as a strong ligand to block the CD44 receptor on the surface of CSC

Classically, HRI has been studied in the context of heme depletion