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No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

Thus, overall, more work needs to be done to determine whether manipulating NAD + levels is effective in reversing ageing-related immunological dysfunction in the adaptive immune system and, equally important, whether such manipulations are safe

Retrieved June 8, 2025, from Institute of Medicine

(2018) 7:e1458809
