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Multifunctional chitosan coated poly(lactic-co-glycolic acid) nanoparticles for spatiotemporally controlled codelivery of ceramide and C-phycocyanin to treat atopic dermatitis

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It is necessary to expand extensive chronic clinical trials to evaluate the long-term safety, efficacy, and optimal dosing of polyphenols, examine gene-diet and microbiota-polyphenol interactions to elucidate inter-individual variability, develop innovative delivery systems to improve bioavailability and facilitate clinical translation, and clarify potential drug interactions and safety in vulnerable populations

[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Petersen A.C., McKenna M.J., Medved I., Murphy K.T., Brown M.J., Della Gatta P., Cameron-Smith D