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The advantages of targeting hypoxia and HIF-1 pathways for AID treatment are multifaceted
10.1016/j.ddmod.2012.02.001 19 FeeW

The results showed that the protocol was well tolerated, providing a mean overall survival time of 904 days, with 60% of dogs alive at the end of the first year and 40% of dogs alive at the end of the second year

Similarly, FH loss leads to the accumulation of fumarate, which can competitively inhibit prolyl hydroxylase that hydroxylate HIF-1 and HIF- 2
