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Inhibition of Cytochrome P450 Enzymes and Biochemical Aspects of Mechanism-Based Inactivation (MBI)
Using an in vitro system of prostate cancer cell lines and patient-derived CAFs, this study visualized exosome uptake and noted that the uptake of these exosomes was followed by a decrease in cancer cell mitochondrial oxidative phosphorylation, concomitantly leading to an increase in glycolysis
Nature 471 (7340), 602607
