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AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of -catenin activation

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Fluctuating or incorrect dosages can lead to symptoms of hypothyroidism, such as fatigue, weight gain, and depression, or hyperthyroidism, such as weight loss, anxiety, and palpitations

Interestingly, autoreactive IgG1 is found in serum early in the clinical development of pemphigus foliaceus, and a subclass switch to IgG4 has been postulated to be an important pathological driver [169]