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Introduction A high blood level of Homocysteine (HCys) has been regarded, in the last 10 years, as a biomarker of cardiovascular disease as well as a risk factor for many other pathologies, including Alzheimer's and other dementias ( Homocysteine (HCys) is a non-essential amino acid that derives from the biosynthesis and metabolism of methionine (Met)

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All of these pathological and biochemical changes were significantly abrogated by feeding the NAD + precursor NAM mononucleotide to mice or overexpressing NAM phosphoribosyltransferase, a rate-limiting enzyme of NAD + biosynthesis, in cardiac tissue (42, 47)

Salts of doubly charged ions CO 3 2- , S 2- , PO 4 3- mostly are insoluble