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At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios

After such a metabolic process as described above, there is no doubt that the metabolism of dietary polyphenols in the human body makes their bioavailability far less than that of direct use in vitro
10.3390/plants9101291 132 MuY.LiuP.DuG.DuJ.WangG.LongA.et al (2009)