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Boyette-Davis et al., 2011, 2013

Thus, LPO not only exacerbates local skin inflammation but may also contribute to systemic oxidative damage in psoriatic patients [35], which correlates with the onset of other associated comorbidities, including cardiovascular diseases and psoriatic arthritis [36,37]

Other pathways involve Src-Family Kinases, p38 MAPK, PINK1-Mediated Mitophagy, and Hippo-YAP signaling pathway

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors