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*Correspondence: Mauricio Di Fulvio, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Caution should be exercised in patients with a history of heart disease, diabetes, hypertension, or kidney problems

Impressively, it generated a bright fluorescent protein, esmGFP, sharing just 58% sequence identity with known proteins, representing an evolutionary gap of approximately 500 million years (Hayes et al., 2025)

This holds particularly true for nucleotides like miRNA, where the negative charge elicits repulsion against the cell membrane, impeding its passive diffusion