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ACS Nano 16 (7), 1090410917
Since it is difficult to modify intrinsic GSH reactivity in the presence of cellular GST, warheads with reduced reactivity are preferred to minimize the non-specific covalent binding burden on proteins, which correlates with the in-vitro reaction rate of the drug and GSH [105,106]
Fernandez JM, Hendricks AJ, Thompson AM, et al
Furthermore, SIRT3 also suppresses HSC response to aging that drives maladaptive trained immunity, aging-associated chronic inflammation and tissue functional decline
