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Acknowledgements The research is supported by the National Key Research and Development Program of China (2020YFA0908200 and 2020YFA0710800), the Key Program of the National Natural Science Foundation of China (81930043 and 82330055), the National Natural Science Foundation of China (T2225003, 82001719, 52073060, and 61927805), the Natural Science Foundation of Jiangsu (BE2018707), the Nanjing Medical Science and Technique Development Foundation (ZKX21019) and the Clinical Trials from Nanjing Drum Tower Hospital (2022-LCYI-ZD-01)