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This process requires two essential amino acids (lysine and methionine), iron (Fe 2+ ), vitamin B 6 in the form of pyridoxal 5-phosphate, niacin in the form of nicotinamide adenine dinucleotide (NAD), and may also require vitamin C (ascorbate) (4)

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Co-supplementation for three months improved both the number of total and intact mitochondria and mitochondrial ultrastructure of neurons in the hippocampus (30)