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Glutathione is a naturally occurring chemical that our liver produces

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Lipids 177, 818

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These regulatory layers coordinately target key enzymes including PHGDH and PSAT1, adapting their expression, stability and activity to meet the metabolic demands of tumor cells, and the regulatory patterns exhibit obvious cancer-type specificity

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Furthermore, the relevance of a Grx(SSR) intermediate and an attack by GSH at the glutaredoxin sulfur atom according to monothiol mechanism (i) were postulated for the reduction of the non-glutathione disulfide bond of the HMA4 domain 60

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