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Analysis of retinas from a glaucoma mouse model fed the KD demonstrated reduced AMPK activation, which was associated with lower NF-B p65 nuclear translocation and decreased expression of pro-inflammatory molecules (40)

William JH, Tapper EB, Yee EU, Robson SC

Since estrogen action is mediated by its receptors, tissues expressing one or more ERs are considered key targets for regulation [32]

Parallel emerging evidence in ischemic reperfusion and neurodegenerative diseases support the presence of both ferroptosis and metabolic dysregulation centred around NADPH and metabolite resources required to synthesise and recycle NADPH