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CXCR4, a GPCR, plays a key role in various biological processes such as hematopoiesis, B cell lymphogenesis, myelopoiesis, and the maintenance of germinal centers (GC)

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5,6,7 Moreover, the damaged liver produces damage-associated molecular patterns (DAMPs) and stimulates inflammatory signals

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These cytokines have been confirmed to contribute to the SG fibrosis by enhancing the local chronic inflammatory environment and inducing the activation of myofibroblasts, especially the macrophage-derived TGF- (121)

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