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This research is largely driven by early biomarker discoveries showing that many ME/CFS patients suffer from a deficiency in serum acylcarnitine, which directly impairs mitochondrial oxidative phosphorylation

Sex Females, or transgendered persons born biologically female, tend to have a higher proportion of fatty tissue and less total body water than males, or transgendered persons born biologically male, of the same weight

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3 The latter affects blood formation, leading to anaemia, a hallmark sign of B12 deficiency