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Studies using animal models of Niemann-Pick disease type A and B (acid sphingomyelinase deficiency) showed that CB1 receptors are downregulated on the surface of neurons probably due to entrapment of the receptor within lysosomes (Vanier, 2010)
[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Chiechio S., Zammataro M., Morales M.E., Busceti C.L., Drago F., Gereau R.W., 4th, Copani A., Nicoletti F

[DOI] [PubMed] [Google Scholar] 6.Cofr E, Peralta OA, Raggi A, De Los RM, Sales F, Gonzlez-Bulnes A, et al
