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Compared to chemical modifications, biological modifications are more specific and have fewer side effects, but they tend to be more costly and less efficient (Zhang et al

To simultaneously decrease DNA synthesis and antioxidant defence of a tumour cell by the inactivation of one enzyme is indeed a tempting approach

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Cells were extracted from the dorsal skin of newborn mice within 24 h after birth, and the dermis and epidermis were separated by floating the dorsal skin in 0.25% trypsin (#150057, Gibco, USA) solution at 4C overnight