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Description
A pattern where the rate of drug elimination is proportional to drug concentration
A 2019 systematic review published in the National Library of Medicine identified improvements in skin brightness across several small trials while emphasising the need for larger controlled studies before definitive claims can be made

doi: 10.1016/j.amjmed.2010.12.027

[DOI] [PMC free article] [PubMed] [Google Scholar] 72
