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Description
It is also used as a supplement in patients undergoing hemodialysis to prevent or correct carnitine deficiency
Interestingly, genetic mouse models of heart-specific CPT I deletion exhibit significant left ventricular systolic dysfunction in response to pressure overload that exacerbates progressively with duration of CPT I gene knockout ( in vivo mechanical deficit induced by chronic CPT I inhibition is paralleled by marked ventricular hypertrophy and an increased susceptibility to premature death (Zhang et al., 2016)
doi: 10.2147/SCCAA.S155410
Bechthold, A
