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RGX-104, an LXR agonist, effectively inhibited the growth of various mouse and human tumors and inhibited myeloid-derived suppressor cell (MDSC) activity by upregulating APOE, which is an LRX target gene, subsequently increasing T-cell activation 156
ACSL4 is generally upregulated in OA cartilage tissue, and its continuous activation expands the pool of oxidizable lipid substrates, thereby significantly increasing the tendency for ferroptosis (Guan et al., 2025
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