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BMP-2: Bone Morphogenic Protein-2 Cana: Canagliflozin CCr: Creatinine Clearance DM: Diabetes mellitus DTNB: 5,5'-Dithiobis-2-Nitrobenzoic Acid GSH: Glutathione MDA: Malondialdehyde NO: Nitric Oxide OS: Oxidative Stress PPi: Inorganic Pyrophosphate ROS: Reactive Oxygen Species Runx2: Runt-Related Transcription Factor SE: Standard Error SGLT2: Sodium-Glucose Cotransporter-2 SIRT1: Sirtuin-1 SOD: Superoxide Dismutase TGF-: Transforming Growth Factor-Beta UCr: Urinary Creatinine VC: Vascular Calcification VSMCs: Vascular Smooth Muscle Cells VDN: Vitamin D3 Plus Nicotine References Amer Ahmed E, El-Sheakh Ahmed R, Hamed Mohamed F, El-Kashef Hassan A, Nader Manar A, Shehatou George S