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In AGA-affected hair follicles, the Wnt / -catenin signaling pathway is dampened, which leads to shorter-growing hair, premature hair shedding, and potentially even hair follicle miniaturization

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22,23 In patients with a normal or low-normal serum vitamin B 12 level, complete blood count results demonstrating macrocytosis, or suspected clinical manifestations, a serum methylmalonic acid level is an appropriate next step 1,2,6,18 and is a more direct measure of vitamin B 12 's physiologic activity