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TB-500, the 43-amino acid form of Thymosin Beta-4 originally isolated from bovine thymus, serves as the dominant G-actin sequestering protein in mammalian cells, orchestrating cytoskeletal dynamics that underlie cellular migration, tissue remodeling, and cardiovascular protection while activating integrin-linked kinase pathways essential for cell survival and repair

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In this review, we briefly introduce the aetiology and epidemiology of several fibrosis diseases, including liver fibrosis, kidney fibrosis, cardiac fibrosis, and pulmonary fibrosis