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Regulation of the proliferation and biosynthetic activities of cultured human Peyronie's disease fibroblasts by interferons-alpha, -beta and -gamma

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Matrix metalloproteinases (MMPs), a zinc-dependent protease family, is induced by several inflammatory cytokines, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and NO ( In summary, the molecular mechanism of PD is a complicated pathological process involved with abnormal signaling pathway, sophisticated interaction in pro/anti-fibrotic cells, and imbalance between accumulation and degradation of collagen