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Roomi et al., 1998 [75] demonstrated that substitution at 2- or 6- and both at 2,6-positions in ascorbic acid have marked cytotoxicity on malignant cells

doi: 10.1111/apt.14689 238

(5.7, 8.1, 8.3) Adverse Reactions/Side Effects The most common adverse reactions (incidence 20%) of ALIMTA, when administered as a single agent are fatigue, nausea, and anorexia

It had no effect on GSH action since the same inhibitory effect was observed in response to 10 mM in presence as well as in absence of BSO
