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Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model

A lack of intracellular cysteine, GSH, or SLC7A11 suppression reduces GPX4 activity, which can enhance lipid peroxidation and trigger ferroptosis (47)

More recently, tofersen (QALSODY ), an antisense oligonucleotide targeting mutant SOD1 , has shown potential in reducing NfL levels and slowing functional decline, though concerns remain regarding inflammatory side effects and the failure of initial phase III trials [7678]