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10 Localized pelvic inflammatory reactions resulted in increased concentration of cytokines, growth factors, and other proinflammatory mediators such as hemoglobin and heme from erythrocytes

In addition, IGF-IR is overexpressed in cancer stem cells and stimulates the expression of stemness transcription factors such as inhibitor of DNA-binding 1, Nanog, and POU5F1 [71, 72]

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Existing research indicates that an increase in sperm DNA damage can affect the developmental potential of embryos post-fertilization, leading to an elevated risk of miscarriage and an increased likelihood of birth defects in offspring (49, 50)