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Zhang and colleagues deposited electrospun TiO 2 nanofibers onto solid supports and functionalized the surface with anti-EpCAM, achieving improved CTC capture from patient samples that included gastric cancer ( Current CTC technologies increasingly prioritize coverage and downstream usability over absolute yield ( A key limitation of EpCAM-centric designs is EMT-associated EpCAM downregulation, which can lead to systematic undercounting of clinically relevant subpopulations ( 5.2 Biomarker enrichment membranes and biosensor integration The same nanotopography-enabled enrichment principles that improve CTC recovery can be repurposed as upstream concentration modules for a broader range of low-abundance biomarkers, enabling integrated sensing workflows for longitudinal gastric cancer monitoring ( Beyond CTC enumeration, gastric cancer surveillance increasingly relies on longitudinal tracking of multiple low-abundance signals, including circulating proteins, nucleic acids, extracellular vesicles, and inflammatory mediators

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