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However, overexpression of 1-hydroxylase in DCs enables production of 1,25(OH)2D in Treg-inducing concentrations without causing hypercalcemia

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While the case-control statistical comparison of metabolomics data cannot distinguish causal from non-causal relationships, the coordinated regulatory network changes identified in xanthine metabolism point to potential clinically relevant disease mechanisms, paving the way for targeted follow-up validation studies

This in turn modulates enzyme activity, ion balance and redox homeostasis in cultured cells, leading to distinct metabolic states (Gstraunthaler et al., 2013)