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This includes patients receiving intramuscular injections (typically 1,000 micrograms) for pernicious anaemia or documented B12 deficiency, as well as individuals taking high-dose oral supplements exceeding the Reference Nutrient Intake (1

Shah Z, Pineda C, Kampfrath T, Maiseyeu A, Ying Z, Racoma I, Deiuliis J, Xu X, Sun Q, Moffatt-Bruce S, Villamena F, Rajagopalan S (2011) Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways

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Tumor suppressor p53, known as the guardian of the genome, contains 12 Cys residues in its amino acid sequence [27], and oxidation of some of these inhibits p53 function [28]