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Major trauma, including heat injury to the skin, results in a profound loss of body nitrogen, altered rates of whole-body protein synthesis and breakdown, and increased nitrogen and amino-acid requirements relative to those in normal, non-stressed individuals
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To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting
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