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In glaucomatous eyes, studies have reported increased TNF- protein levels, elevated TNF- gene expression in glial cells, and upregulated TNF- receptor 1 in RGCs [65]
doi: 10.1128/IAI.00117-07 294 SmithH.YatesE
Variations in the gene can either cause aberrant redox signaling and increase reactive oxygen species, leading to oxidative stress, or lead to higher selenoprotein enzyme levels and reduced oxidative damage, depending on which variation you have
