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Nrf2 then translocates into the nucleus and binds to antioxidant response elements in the promoter region of several antioxidant genes, such as heme-oxygenase-1 and NADPH-quinone-oxidoreductase-1

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[DOI] [PubMed] [Google Scholar] 38.Erra Daz F, Ochoa V, Merlotti A, Dantas E, Mazzitelli I, Gonzalez Polo V, Sabatt J, Amigorena S, Segura E, Geffner J

Arginase inhibitors have been developed and experimentally evaluated in various tumors